3) The first relapse (return of cancer)

End of 1995, said Shifra clinical cancer. This means that no leukemia can be demonstrated. It may well be that there are still cancer cells present, but there are so little that the current equipment to trace. In the spring of 1997 (May) is when the leukemia returned Shifra. A recurrence by 89% blasts, which are wrong "cells." After one month she was again in remission (the wrong amount of "cells" is less), but October 1997, after a remission of only four months, she gets her second relapse.

Usually a first relapse looked at the possibility of a bone marrow transplant. But because Shifra's parents and siblings had no bone marrow that had reached the (donor), the physician in Groningen (The University Hospital) to re-start of chemotherapy. According to the doctor, the chances of recovery with chemotherapy as big as a beenmergtranplantatie.

Cor and Marina have now had to find out whether the World Bank, donor or donors were Shifra. (Eg by a covering letter to the clinic in Groningen nav HLA typing by the laboratory for transplantation immunology, dated June 10, 1997, and a search in Bone Marrow Donors World Wide (May 1997), yielded 15 potential donors.

Yet Marina and followed the advice of the Cor doctor and was again started chemo.

ALL relapse protocol SNLWK 90 with 3 blocks where chemotherapy was administered the following programs:

Dexamethasone , 6-mercaptopurine (6-MP) , Vinchristine (VCR) HD-Methotrexate (HD-MTX) , 6-Thioguanine (6-TG) , Vindesine (VDS) , HD ARA-C , Etoposide (VP-16) L-ase (L-Asp)

Shifra gets severe bone pain and reducing Shifra will be a measure corset that she has day and night.