Brain Tumors: Immunotherapy based on dendritic cells (stem cells) appears effective in animal studies in brain tumors - glioblastoma. Article posted March 11, 2010
June 22, 2011: Please read the recently added information about Dr. Robert Gorter and Medical Center in Cologne this information: My experience with dr.Robert Gorter and the Medical Center Cologne. A warning
And click here for addresses of clinics in Germany, where dendritic cell therapy is given .
March 11, 2010: Source: cellular immune Therapeutics, Ltd.
Immunotherapy based on dendritic cells - stem cells appears in a randomized preclinical study in rats with brain tumors - Glioblastoma effective. Or so says a press release from the producer of the investigational vaccine. The rats were divided into two groups. One group received a vaccine based on the removed tumor tissue. The other group received a vaccine based on stem cells (dendritic cells). The rats on the basis of the removed tumor tissue were immunized all died. 30% of the group of rats were treated with dendritic cell therapy using stem cells survived long term.
cellular immune Therapeutics "Dendritic Cell-Based Vaccine Demonstrates Statistically Significant Increase in Survival in an Animal Model of Glioblastoma
LOS ANGELES, March 10, 2010 (BUSINESS WIRE) - cellular immune Therapeutics, Ltd.. (OTC.BB: IMUC) Announced Today That its dendritic cell based vaccination with cancer stem cells (CSCs) demonstrated a statistically significant survival benefit in a preclinical animal model of glioblastoma. The rats were immunized Either with cancer stem cells (CSCs) from a brain tumor or cancer cells the daughter (the bulk of the tumor), and results showed That Those immunized with the CSCs had a median survival of 50 days compared to 29 days for daughter cells. Further More, 30% of animals vaccinated against cancer stem cells demonstrated long-term survival as compared to animals vaccinated with the bulk of the tumor, all of Which died.
"We are excited by the study's results, as it Represents a significant step forward in the continued development of our cancer stem cell-based vaccines," said Dr.. Manish Singh, PhD., President and CEO or cellular immune therapeutics. "The data validates our research Further targeting CSCs Indicating That Has The Potential to be a highly effective method of treating cancers Various Artists." The data demonstrated Also Increased gamma-interferon levels in animals Treated with CSCs, Indicating an Increased immune response consistent with Increase in survival Further supporting the mechanism of action of this approach
The Company's recently completed Phase I trial of its lead cancer vaccination product candidate IT-107, an active immunotherapy Developed from studies conducted by immune cellular Therapeutics, showed That targeting 'certain specific antigens That are highly Expressed on cancer stem cells (CSCs) can lead to significant benefit in progression free survival as well as overall survival in GBM Patients




