Operation: post-operative treatment: If darmkanker soliciting patients water and salt get added to the stool to get this going again deteriorates their recovery and lengthens hospital stay with three days, is 50% longer, thus randomised study.

15 June 2005: source: The Lancet. 2002 May 25; 359 (9320): 1812-8.
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Darmkanker patients when directly after surgery salt and water krjgen infused with the aim to relaunch the stool is done just the opposite. The stool comes later on gang and the duration of stay in the hospital but is leifst with three days = 50%, extends a high significant difference. All this shows from a randomized study, published in The Lancet in 2002.
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Comment in:
Lancet. 2002 May 25; 359 (9320): 1792-3.
Lancet. 2002 Nov 23; 360 (9346): 1699; author reply 1699-700.
Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial.
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Lobo DN, Bostock KA, Neal KR, Perkins AC, Rowlands BJ, Allison SP.
Section of Surgery, University Hospital, Queen's Medical Centre, Nottingham, UK. dileep.lobo@nottingham.ac.uk
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BACKGROUND: Low concentrations or albumin in serum and pulmonary gastric emptying times have been returned to normal in dogs by salt and water restriction, or a high protein intake. We aimed to determine the effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection in human beings.
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METHODS: We randomly allocated in postoperative patients to receive intravenous fluids in accordance present hospital practice (> or = 3 L water and 154 mmol sodium per day) and at to receive a restricted intake (or < = 2 L water and 77 mmol sodium per day). All patients had no disease other than colonic cancer. The primary endpoint was solid and liquid-phase gastric emptying time, measured by dual isotope radionuclide scintigraphy on the fourth day postoperative. Secondary endpoints included time to first bowel movement and length of postoperative hospital stay. Analysis was by intention to treat.
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FINDINGS: Median solid and liquid phase gastric emptying times (T (50)) on the fourth day postoperative were significantly longer than in the standard group in the restricted group (175 vs 72.5 min, difference 56 [95% CI 12-132], p = 0.028; and 110 vs 73.5 min, 52 [9-95], p = 0.017, respectively). Median passage or flatus was 1 day later (4 vs. 3 days, 2 [1-2], p = 0.001); median passage or stool 2.5 days later (6.5 US 4 days, 3 [2-4], p = 0.001); and median postoperative hospital stay 3 days longer (9 vs 6 days, 3 [1-8], p = 0.001) than in the standard group in the restricted group. One patient in the restricted group developed hypokalaemia, whereas seven patients in the standard group had side-effects or complications (p = 0.01).
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INTERPRETATION: Positive salt and water balance sufficient to cause a 3 kg weight gain after surgery delays return of gastrointestinal function and prolongs hospital stay in patients undergoing electivecolonic resection.
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Publication Types:
Clinical Trial
Randomized Controlled Trial
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PMID: 12044376 [PubMed-indexed for MEDLINE]