Antioxidants: Prenatal use of extra multivitamins provides significantly less risk of leukemia and brain tumors in children in their childhood. This shows a large meta analysis of over 60 randomized trials. Article posted March 25, 2007
March 25, 2007: Source: 1: Clin Pharmacol There. 2007 in February 1921;Use of additional prenatal multivitamins provides significantly less risk of childhood leukemia and brain tumors in childhood. This shows a large meta analysis of over 60 randomized trials.
Prenatal Multivitamin supplementation and Rates of Pediatric Cancers: A Meta-Analysis. Goh YI, Bollano E, Einarson TR, Koren G.
[1] 1Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada [2] 2The Motherisk Program, Division of Clinical Pharmacology / Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Prenatal folic acid supplementation or Has Been Shown to Decrease the Risk of Several congenital Malformation. Several studies have Recently Suggested a potential protective effect of folic acid on Certain pediatric cancers. The protective role or prenatal multivitamins HAS leg not elucidated. We Conducted a systematic review and meta-analysis to Assess the potential protective effects or prenatal multivitamins on Several pediatric cancers. Medline, PubMed, EMBASE, Toxline, Health Star, and Cochrane databases Were searched for studies published in all languages from 1960 to July 2005 on multivitamin supplementation and pediatric cancers. References from all articles reviewed for Additional Were Collected articles. Two blinded independent reviewers assessed the articles for inclusion and exclusion. Rates of cancers in women supplemented with multivitamins compared with unsupplemented women Were Using a random effects model. Sixty-one articles Were Identified in the initial search, or Which, seven articles with the inclusion criteria.
There was an apparent protective effect for leukemia (odds ratio (OR) = 0.61, 95% confidence interval (CI) = 0.50-0.74), pediatric brain tumors (OR = 0.73, 95% CI = 0.60-0.88) and neuroblastoma (OR = 0.53, 95% CI = 0.42-0.68). In Conclusion, maternal been stationed or prenatal multivitamins is associated with a Decreased risk for pediatric brain tumors, neuroblastoma, and leukemia. Presently, it is not Known Which constituent (s) among the multivitamins confer this protective effect.Clinical Pharmacology & Therapeutics advance online publication, 21 February 2007. doi: 10.1038/sj.clpt.6100100.
PMID: 17314929 [PubMed - as supp song by publisher]
