Scientific research on nutrition and natural approaches and resources in cancer. Studieabstracten study and analysis.

Here we list articles and studies or research on cancer in relation to nutrition. With some additional comments other as we found on the Internet. We will complement these articles regularly, but that takes time and we want very carefully. We have tried to research and articles in logical and more or less alphabetical order. Often an article in the name of nutrient - vitamin etc. But sometimes in diets or diet in cancer or cancer type out the first named, including bladder cancer and vitamins in the BA. So take the name of one nutrient or use search to start because of various cancers are also often important studies and articles that are not all in this list.

If there are people who can give us tips like please send us remarkable investigations and we post on the site. (See also reading list ( This list compiled by physician-biologist Erik Valstar has exceeded 1500 and are all randomized trials) and cancer rates ). In addition, a recommendation to information on proven effects of diet and nutritional supplementation in cancer of the book: Nutritional intervention in cancer, a signal to the conventional oncology. Because physician-biologist Dr Engelbert Valstar. The book costs 16.95 and the ISBN number is 90 5860 192 7.

In the left column we have posted articles on more or less alphabetical order. Sometimes the name of agent (eg Chinese herbs or form of treatment such as acupuncture or cancer such as colon cancer

Calcium appears to preventive work in preventing colon cancer, says study with animals.

Source: Journal of the National Cancer Institute , Vol. 96, no. 12, 921-925, June 16, 2004

Calcium, the growth of malignant polyps counter and is basically preventive in preventing colon cancer. Thus, a study published in the Journal of the NCI. Arts biologist Dr E. Valstar we confirmed that calcium has a strong preventive effect on the risk of getting colon cancer but also other cancers such as prostate cancer.
In his book "Nutritional intervention in cancer," he discusses the effect of calcium in treatment of cancer with much more than these literature studies, including literary studies in humans.

What is striking in the study description is this sentence: "Clinical trials have already shown that calcium-containing dietary supplements the risk of colon cancer reduction. A new study indicates that this inhibitory effect is mainly related to the progression of pre-malignant polyps." Thus is implicitly confirmed that calcium plays a role in a cancer trial.

In this randomized double-blind study included 930 patients whose cancer cells were found previously. One group received daily 1200 mg of calcium carbonate, the other half a placebo. The patients received regular bowel investigation for the presence and growth of malignant polyps check.

The risk in the calcium group at the origin of 'hyperplastic polyps "or" tubular adenoma "was 0.82 and 0.89 respectively. However, compared to placebo, the risk of colon cancer in the calcium group, 0.65. The results indicate that calcium mainly affects the final stage of cancer formation of polyps.

Here the original abstract of the study:

Source: Journal of the National Cancer Institute , Vol. 96, no. 12, 921-925, June 16, 2004

Effect of calcium supplementation on the Risk of Large Bowel Polyp
Kristin Wallace, John A. Baron, Bernard F. Cole, Robert S. Sandler, Margaret R. Karagas, Michael A. Beach, Robert W. Haile, Carol A. Burke, Loretta H. Pearson, Jack S. Mandel, Richard Rothstein, Dale C. Snover

Affiliations of authors: Departments of Community and Family Medicine (KW, JAB, BFC, MRK, LHP), Medicine (JAB, RR), and Anesthesia (MAB), Dartmouth-Hitchcock Medical Center, Lebanon, NH, Department of Medicine, University of North Carolina, Chapel Hill (RSS), Department of Preventative Medicine, University of Southern California School of Medicine, Los Angeles (RWH) Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH (CAB), Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (JSM), Department of Pathology, Fairview Southdale Hospital, and Department of Pathology, University of Minnesota, Minneapolis (DCS)

Correspondence to: John A. Baron, MD, Dartmouth Medical School, Evergreen Center, Suite 300, 46 Centerra Parkway, Lebanon, NH 03756 (e-mail: john.a.baron @ dartmouth.edu)

Background: Clinical trials have Shown That calcium supplementation modestly decreases the risk of colorectal adenomas. However, few studies have Examined the effect of calcium on the risk of differential types of colorectal lesions or dietary determinants of this effect.

Methods: Our analysis from the Used patiënten Calcium Polyp Prevention Study, a randomized, double-blind, placebo-controlled chemo-prevention trial among Patients with a recent colorectal adenoma. Nine hundred thirty Patients Were Randomly Assigned to calcium carbonate (1200 mg / day) or placebo. Follow-up colonoscopies Were Conducted approximately 1 and 4 years after the qualifying examinations. We Used general estimating equations (GEE) and generalized linear regression analysis to compute risk ratios and 95% confidence intervals (CIs) to Assess the effect of calcium treatment versus placebo on the risk of hyper-plastic polyps, tubular adenomas, and more advanced lesions. Additionally, we Used GEE analysis to compare the calcium treatment effects for Various types of polyps with That for tubular adenomas. We Also Examined the Interaction Between calcium treatment and baseline intake of dietary calcium, fat, and fiber. All P values Were Obtained Using Wald tests based on the correspondence models thing. All tests of statistical significance Were two-sided.

Results: The calcium risk ratio for hyper-plastic polyps was 0.82 (95% CI = 0.67 to 1.00), That for tubular adenomas was 0.89 (95% CI = 0.77 to 1.03), and for Thathistologically advanced neoplasms was 0.65 (95% CI = 0.46 to 0.93) compared with placebo patiënten Assigned to. Were there no statistically significant differences Between the risk ratio for tubular adenomas and for That Other types of polyps. The effect of calcium supplementation on adenoma risk was musts pronounced among Individuals with high dietary intakes of calcium and fiber and with low intake of fat, but the interactions Were not statistically significant.

Conclusion: Our results suggest calcium supplementation That May have a more pronounced antineoplastic effect on advanced colorectal lesions on Than Other types of polyps.

-------------------------------------------------- ------------------------------ This article Has Been cited by Other articles in Highwire Press-hosted journals:
Schatzkin, A., Peters, U. (2004). Advancing the Calcium-Colorectal Cancer Hypothesis. J Natl Cancer Inst 96:893-894