Liver cancer.

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Nutrition and nutrients: combination of synbiotica (= multiple types of probiotics) reduces significantly (12% t. ot 30%) chance of serious inflammations in surgery of primary liver tumors. Article update 16 October 2011

29 October 2006: source: Ann Surg 2006 Nov; 244. (5): 706-714.

When patients with operable rectal primary liver cancer food in advance synbiotica (= mix of different types of probiotics) then get they run significantly less risk of getting serious inflammation related to the operation. Also all gave a significantly more positive image in the immuunmarkers in the Group of patients than in the group without synbiotica. This is the of messages matching a randomized study in 100 patients with primary operable rectal liver cancer.

Perioperative Synbiotic Treatment to Prevent Postoperative Infectious Complications in Biliary Cancer Surgery: A Randomized Controlled Trial.
Sugawara G, M, H, T, Nagino Nishio, Aichi Ebata K, Nomoto K, Takagi T, Y Asahara Nimura.
From the * Department of Surgery, Division of Surgical Oncology; Nagoya University Graduate School of Medicine, Nagoya, Japan; daggerNagoya University College of Medical Technology, Nagoya, Japan; Central Institute for Microbiological Research and double daggerYakult, Tokyo, Japan.

SUMMARY BACKGROUND DATA:: Use of synbiotics has been reported to benefit human health, but clinical value in surgical patients remains unclear.

OBJECTIVE: To investigate the effect of oral administration of intestinal barrier function perioperative synbiotics upon immune responses, systemic inflammatory responses, micro, flora, and surgical outcome in patients undergoing resection hepatobiliary high-risk.

METHODS: Patients with biliary cancer involving the hepatic hilum (n = 101) were randomized before hepatectomy, into a group receiving postoperative enteral feeding with synbiotics (group A); or another receiving preoperative postoperative synbiotics (group B) plus. Lactulose-mannitol (L/M) serum diamine oxidase (DAO) activity, ratio, natural killer (NK) cell activity, interleukin-6 (IL-6), fecal microflora, and fecal organic acid concentrations were determined before and after hepatectomy. Postoperative infectious complications were recorded.

RESULTS:: Or 101 patients, 81 completed the trial. Preoperative and postoperative changes in L/M ratio and DAO activity were similar between groups. In group B, NK activity Preoperatively, and lymphocyte counts decreased significantly increased, while IL-6 (P< 0.05).="" postoperative="" serum="" il-6,="" white="" blood="" cell="" counts,="" and="" c-reactive="" protein="" in="" group="" b="" were="" significantly="" lower="" than="" in="" group="" a="" (p="">< 0.05).="" during="" the="" preoperative="" period,="" numbers="" of="" bifidobacterium="" colonies="" cultured="" from="" and="" total="" organic="" acid="" concentrations="" measured="" in="" feces="" increased="" significantly="" in="" group="" b="" (p="">< 0.05).="" postoperative="" concentrations="" of="" total="" organic="" acids="" and="" acetic="" acid="" in="" feces="" were="" significantly="" higher="" in="" group="" b="" than="" in="" group="" a="" (p="">< 0.05). Incidence of postoperative infectious complications was 0.05).="" incidence="" of="" postoperative="" infectious="" complications="" was="">30.0% (12 or 40) in group A and 12.1% (5 or 41) in group B (P<>

CONCLUSIONS: oral administration can enhance immune responses Preoperative or postoperative synbiotics attenuate inflammatory responses, systemic, and improve intestinal microbial environment. These beneficial effects likely reduce postoperative infectious complications after resection for biliary tract cancer hepatobiliary.

PMID: 17060763 [PubMed-as supplied bypublisher]