Dendritic cell therapy in general: Dendritic cell therapy accompanied by super paramagnetic iron oxide formulation or (111) In-oxine = thin iron particles gives better control of dendritic cell therapy works so well Nijmegen researchers report in a study report. Article posted November 2005
November 5, 2005: Source: Nat Biotechnol. 2005 Oct 30;
Nijmegen researchers at Radboud present a successful investigation into the use of "iron particles" (super paramagnetic iron oxide formulation or (111) In-oxine = thin iron particles) to verify that the cultured dendritic cells in the right place into the body come. Now more and more nanoparticles or other injectable devices used to such a radiation dust or certain medicines only in the tumors to get healthy cells to avoid thinking of such nano therapy and / or internal radiation for prostate cancer and internal radiation from carcinoid the past several years has proven an effective treatment. Interesting now is that dendritic cells are injected under the guidance of "super-paramagnetic iron oxide formulation or (111) In-oxine" to control the operation of the treatment. The injection is done through the lymph / the lymphatic system, we have been told and is also in the following abstract. The following abstract does not say that much for laymen like us but we know through our contacts in the Radboud such that this method for several cancer ( melanoma patients, for example) a long lasting vollledige remission of their cancer have achieved.
Look for nice explanation with pictures etc. clarifying how this approach works on this Website
Nat Biotechnol. 2005 Oct 30;
Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy.
de Vries IJ, Lesterhuis WJ, Barentsz JO, Verdijk P, van Krieken JH, Boerman OC, Oyen WJ, Bonenkamp JJ, Boezeman JB, Adema GJ, Bulte JW, CAL Ones TW, Punt CJ, Heerschap A, Figdor CG.
[1] Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grootplein 28, 6500 HB Nijmegen, The Netherlands. [2] Department of Pediatric Oncology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grootplein 28, 6500 HB Nijmegen, The Netherlands.
The success of cellular therapies Will depend in part on accurate delivery to target cells or organs. In dendritic cell therapy, in Particular, delivery and Subsequent migration to regional lymph nodes or cells is essential for effective stimulation of the immune system. We show here That in vivo magnetic resonance tracking of magnetically labeled cells is Feasible in humans for detecting very low numbers of dendritic cells in Conjunction with detailed anatomical information. Autologous dendritic cells were labeled with a clinical super paramagnetic iron oxide formulation or (111) In-oxine and were co-injected into melanoma patients under ultrasound intranodally guidance. In contrast to scintigraphic imaging, magnetic resonance imaging (MRI) allowed assessment of the accuracy of dendritic cell delivery and of inter-and intra-nodal cell migration patterns. Using iron oxide MRI cell tracking Appears Clinically safe and well suited to monitor cellular therapy in humans.
PMID: 16258544 [PubMed - as supplied by publisher]
