Lymphoma. Hodgkinlymfomen and non-Hodgkin's disease

Information on current developments in both regular and alternative or complementary treatments and resources for lymphoma - non-Hodgkin's lymphoma and Hodgkin's disease at all stages.

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Diagnosis of lymphoma: Lymphoma can now be better defined by new diagnostic method.

March 8, 2004: Lymphoma can now be better defined by new diagnostic method

Source: Erasmus Medical Center

European cooperation leads to new DNA diagnostic method

Rotterdam, March 8 - With a new method for DNA diagnostics, it is possible to quickly and reliably determine lymph node cancer. Previously, the diagnosis of this disease in about 10 to 15% of cases are difficult and not with any confidence. The development and standardization of the new method was worked by 47 research institutes in seven European countries, led by Professor Jacques JM van Dongen and Dr. Ton Langerak of the Department of Immunology of Erasmus MC and Prof. Han van Krieken of the Department of Pathology of the Hospital St. Radboud in Nijmegen.
Approximately 4,000 patients in the Netherlands tested for lymph node cancer. In many cases, the usual investigation to determine whether or not the disease exists. In about 10 to 15% of cases provide the current diagnostic methods can not be determined. In those cases, costly additional research is needed, the results are not complete certainty. Moreover, while additional research is not always the treatment instituted.

By pooling their knowledge and experience, researchers from 47 institutes in seven European countries have succeeded in rapid and reliable DNA diagnostics development for identifying lymph node cancer. The method uses the fact that this disease all of a cancer cell derived (clonally), and thus have identical DNA, which is identical rearranged antibody and T-cell receptor genes. Removal of the new "clonality" - test may be diagnosed with great certainty.

The research was partly funded by the European Union. The results of the survey in December 2003 published in the authoritative international journal Leukemia. The developed method has led to patents in Europe and the United States, where the test is now in much clinical research has been introduced. European researchers are planning to invest in royalties next collaborative.