CANCER.
Information on current developments in both regular and alternative or complementary treatments for cancer types and resources at all stages. We have basically all articles and information put in alphabetical order, scroll in left column in alphabetical list.
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Hedgehog, a bodily substance may play crucial role in development of intestinal cancer. Article posted February 14, 2004
dated February 14, 2004: Source: Nature Genetics
Lack of the body's own substance Indian hedgehog may adenocarcinoma lead Dutch researchers said in vitro studies.
The Dutch researchers Gijs van den Brink and Sylvia Bleu Ming worked in the AMC - Amsterdam have discovered that the fabric Indian Hedgehog may play a decisive role in the development of colon cancer. In laboratory tests showed that in healthy intestinal tissue that dust was present in cancer cells. Indian Hedgehog plays a crucial role in the development of specialization of cells and the natural process of apoptosis (cell suicide) . During the investigation it was discovered that before the intestinal cells to specialize in the production of Indian Hedgehog already under way. If this substance is absent mature cells, but they can also proliferate and cancer cells. Now in vitro by the Indian hedgehog fabric to add the specialization process was resumed and was again the connection was restored the natural process of apoptosis. Now we are not medical experts but it seems to us a special and important discovery. If doctors or scientists want to comment on it before us, we feel that we recommend. Send us an email if you are an expert has something to say.
Source: Nature Genetics: February 8, 2004, doi: 10.1038/ng1304
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
Gijs R van den Brink1, 6, Sylvia A. Bleuming1, 6, James CH Hardwick1, Berber Schepman1 L, G Johan Offerhaus2, J Josbert Keller2, Corinne Nielsen3, William Gaffield4, Sander JH van Deventer5, Drucilla J & Maikel P Roberts3 Peppelenbosch1
Wnt signaling defines the colonic epithelial progenitor cell phenotype1, and Mutations in the gene adenomatous polyposis coli (APC) That activate the Wnt pathway cause the familial adenomatous polyposis coli (FAP) syndrome and must cancers2 Sporadic colon. The Mechanisms That Regulate the transition of epithelial precursor cells Writing Their differentiated derivatives are poorly characterized. We report That Indian hedgehog (Ihh) is overexpressed by mature colonocytes and regulates Their differentiation in vitro and in vivo. Hedgehog (Hh) signaling restrict the expression of Wnt targets to the base of the colonic crypt in vivo, and Transfection of Ihh Writing colon cancer cells leads to a downregulation of both components of the nuclear TCF4 - catenin complex and abrogates endogenous Wnt signaling in vitro. In turn, expression of Ihh is downregulated in polyps or Individuals with FAP and expression and doxycycline-inducible dominant negative TCF4 (dnTCF4) restores Ihh expression in APC mutant DLD-1 colon cancer cells. These data identify a new Wnt-Hh axis in colonic epithelial renewal.
Lack of the body's own substance Indian hedgehog may adenocarcinoma lead Dutch researchers said in vitro studies.
The Dutch researchers Gijs van den Brink and Sylvia Bleu Ming worked in the AMC - Amsterdam have discovered that the fabric Indian Hedgehog may play a decisive role in the development of colon cancer. In laboratory tests showed that in healthy intestinal tissue that dust was present in cancer cells. Indian Hedgehog plays a crucial role in the development of specialization of cells and the natural process of apoptosis (cell suicide) . During the investigation it was discovered that before the intestinal cells to specialize in the production of Indian Hedgehog already under way. If this substance is absent mature cells, but they can also proliferate and cancer cells. Now in vitro by the Indian hedgehog fabric to add the specialization process was resumed and was again the connection was restored the natural process of apoptosis. Now we are not medical experts but it seems to us a special and important discovery. If doctors or scientists want to comment on it before us, we feel that we recommend. Send us an email if you are an expert has something to say.
Source: Nature Genetics: February 8, 2004, doi: 10.1038/ng1304
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
Gijs R van den Brink1, 6, Sylvia A. Bleuming1, 6, James CH Hardwick1, Berber Schepman1 L, G Johan Offerhaus2, J Josbert Keller2, Corinne Nielsen3, William Gaffield4, Sander JH van Deventer5, Drucilla J & Maikel P Roberts3 Peppelenbosch1
Wnt signaling defines the colonic epithelial progenitor cell phenotype1, and Mutations in the gene adenomatous polyposis coli (APC) That activate the Wnt pathway cause the familial adenomatous polyposis coli (FAP) syndrome and must cancers2 Sporadic colon. The Mechanisms That Regulate the transition of epithelial precursor cells Writing Their differentiated derivatives are poorly characterized. We report That Indian hedgehog (Ihh) is overexpressed by mature colonocytes and regulates Their differentiation in vitro and in vivo. Hedgehog (Hh) signaling restrict the expression of Wnt targets to the base of the colonic crypt in vivo, and Transfection of Ihh Writing colon cancer cells leads to a downregulation of both components of the nuclear TCF4 - catenin complex and abrogates endogenous Wnt signaling in vitro. In turn, expression of Ihh is downregulated in polyps or Individuals with FAP and expression and doxycycline-inducible dominant negative TCF4 (dnTCF4) restores Ihh expression in APC mutant DLD-1 colon cancer cells. These data identify a new Wnt-Hh axis in colonic epithelial renewal.
1. Department of Experimental Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands.
2. Department of Pathology, Academic Medical Center, Amsterdam, the Netherlands.
3. Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
4. Western Regional Research Center, ARS, USDA, Albany, California, USA.
5. Department of Gastroenterology, Academic Medical Center, Amsterdam, the Netherlands.
6. These authors Equally contributed to this work.
Correspondence Should Be Addressed to GR van den Brink. E-mail: grvandenbrink@amc.uva.nl
2. Department of Pathology, Academic Medical Center, Amsterdam, the Netherlands.
3. Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.
4. Western Regional Research Center, ARS, USDA, Albany, California, USA.
5. Department of Gastroenterology, Academic Medical Center, Amsterdam, the Netherlands.
6. These authors Equally contributed to this work.
Correspondence Should Be Addressed to GR van den Brink. E-mail: grvandenbrink@amc.uva.nl
