Hyperbaric oxygen therapy after irradiation gives significantly better quality of life in patients who are irradiated for cancer in mouth and nose area. Article update 2 February 2012
9 October 2009: source: Radiation Oncology magazine
u000dHyperbaric oxygen therapy after irradiation gives significantly better quality of life in patients who are irradiated for cancer in mouth and nose area. Dutch researchers conclude from a small-scale but this randomised study at 19 patients with tongue and nose cancer. Onderzoekspunten at all for quality of life, such as better swallow, less dry mouth by reduced saliva production and also pain in the mouth, the patients who scored the hyperbaric oxygen therapy had significantly better than the patients who had no hyperbaric oxygen therapy.
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Early Hyperbaric Oxygen Therapy for Reducing Radiotherapie Side Effects: Early Results of a Randomized Trial in Oropharyngeal and Nasopharyngeal Cancer
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Est, R.T.T.
, Peter van Rooij, m.SC., Antoine g. Dumans, M.D., d.d.s.†, Maarten f. de Boer, M.D., Ph.d.,‡ Michiel P.C. van der Huls, M.D.‡, Wouter Strong, M.D., Ph.d. Paul Schmitz I.M.‡,¶ , Ph.d.u000du000du000d
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Received 24 July 2008; received in revised form 24 November 2008; accepted 27 November 2008. published online 21 April 2009.
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Purpose
Comparison of quality of life (QoL) and side effects in a randomized trial for early hyperbaric oxygen therapy (HBOT) after radiotherapie (RT).
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u000dMethods and Materials
u000dFrom 2006, 19 patients with tumor originating from the tonsillar fossa and/or soft palate (15), base of tongue, nasopharynx (1) and (3) were randomized to receive HBOT or not. HBOT consisted of 30 sessions at 2.5 ATA (15 msw) with oxygen breathing for 90 min daily, 5 days per week, applied shortly after the RT treatment was completed. As of 2005, all patients received b validated (i.e., the European Organization for Research and Treatment of Cancer, EORTC QLQ-C30 QLQ 38320450-Head and Neck Cancer Module (H & N35), Performance Status Scale): before treatment; at the start of RT treatment; after 46 Gy; at the end of RT treatment; and 2, 4, and 6 weeks and 3, 6, 12, and 18 months after follow-up.
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u000dResults
u000dOn all items, better QoL scores were obtained in patients treated with hyperbaric oxygen. The difference between HBOT vs. non-HBOT was significant for all parameters: EORTC H & N35 (p = 0.011) Swallowing, EORTC H & N35 Dry Mouth (p = 0.009), EORTC H & N35, Sticky Saliva (p = 0.01), PSS Eating in Public (p = 0.027), and Pain in Mouth (visual analogue scale; < p 0.0001).
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u000du000dConclusions
u000dPatients randomized for receiving hyperbaric oxygen after the RT had better QoL scores for swallowing, sticky saliva in mouth, xerostomia, and pain.
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