August 10, 2009: Source: Pubmed and Kennislink. Thanks to William
Spanish researchers have found a substance that cancer cells start to destroy themselves (apoptosis). In a study of mice with melanoma found that the mice that the fabric had administered had significantly lower burden of cancer and disappeared in a majority of the mice to melanoma because the immune system the cancer was removed by inserting a fabric that double-stranded RNA mimics.
Quote from Kennislink: There is much research on molecular mechanisms that may explain the resistance of melanoma. The cells appear to possess complex tribufos, making it very difficult to destroy them. It is Spanish scientists now succeeded in an unexpected weakness in this defense to discover. Like most animal cells are cells of a melanoma to death of double-stranded RNA. The cells associated with this form of RNA viruses and thereby set in motion a reaction which they destroy themselves.
Now we know that melanoma cells respond to so much double-stranded RNA, we can abuse it. There are synthetic compounds which mimic double-stranded RNA. An example is PIC. When PIC enters the cytoplasm of cancer cells in an immune reaction that set in motion that ultimately leads to cell death. For the efficacy of PIC is transported to the cytoplasm criticism, but the fabric can not regulate itself. Therefore, PIC be released in conjunction with a carrier, which creates a complex.
However, the researchers stress that it will take many years for this fabric can be used in people with cancer. Nevertheless devotes Kennislink (site of the government for young people and students) wrote an article. Read here what Kennislink else writes about.
And here the abstract of the study.
1: Cancer Cell. 2009 August 4, 16 (2) :103-14. Left
- Comment in:
- Cancer Cell. 4 August 2009, 16 (2) :83-4.
Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells.
Tormo D ,
Checiñska A ,
Alonso-Curbelo D ,
Perez-Guijarro E ,
Cañón E ,
Riveiro-Falkenbach E ,
Calvo TG ,
Larribere L ,
Megías D ,
Mulero F ,
Piris MA ,
Dash R ,
Barral PM ,
Rodríguez-Peralto JL ,
Ortiz-Romero P ,
Tüting T ,
Fisher OJ ,
Soengas MS .
Melanoma Laboratory, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Inappropriate drug delivery, secondary toxicities, persistent and chemo-and immuno-compromised resistance possessions traditionally Treatment Response in Melanoma. Using cellular systems and Genetically Engineered mouse models, we melanoma cells Retain That shows an innate ability to Recognize cytosolic doubled-stranded RNA (dsRNA) and mount programs "are persistent stress response-able to block tumor growth, as in highly immunosuppressed backgrounds. The dsRNA mimic polyinosine-polycytidylic acid, coadministered with polyethyleneimine as carrier, was Identified as an unanticipated Inducer or autophagy downstream or exacerbated an endosomal maturation programs. A competitive activity of the dsRNA helicase MDA-5 driving the proapoptotic protein NOXA resulted into an efficient car Digestion or melanoma cells. These results left for therapeutic intervention Reveal tractable Among dsRNA helicases, endo / lysosomes, and apoptotic factors.
