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novel protein found on side effects of radiotherapy. Article archive posted May 21, 2011
July 26, 2009: Thanks to Bill. Link to original English article below is translated article
Israeli researchers have worked with U.S. researchers at a U.S. military medicine found that protects people from the harmful effects of radiation. Both of radiation emitted by the use of nuclear weapons and "dirty bopmbs" by terrorists as radiation used to treat cancer patients. Gudkov's discovery can be very positive for cancer because cancer doctors can better protect against radiation. The new drugs make it possible to treat cancer with radiation as powerful while combating the disease can greatly improve. This, the researchers in a press release. Randomized studies with both mice and monkeys showed geljike spectacular results. Studies in humans the safety of this drug showed 100% safety of this drug. The drug works as in the period 24 hours to 72 hours after exposure to radiation is given by injection. The difference in survival and / or serious adverse events between groups of mice and monkeys was almost 100% in favor of the drug. An extremely spectaculiare invention. The U.S. government has already invested 40 million U.S. dollars in this project and thus onderzoerks in a press release is expected within 2 years can be transferred to mass production for use eg in the treatment of cancer patients in combination with radiation.
Here with the help of a free translation of an article on google news this opmerkeljike
The drug, developed by Professor Andrei Gudkov - Chief Scientific Officer of Cleveland BioLabs - can have far reaching consequences for the balance of power in the world, and shall be able to Isreal to protect their citizens from radiation. It wil have an important strategic advantage over their competitors.
For Israel, this discovery marks a very dramatic development that could have a huge impact on the key issues in defensive areas: protection against a nuclear attack against Iran or "dirty bomb" attacks by terrorist groups.
Gudkov's discovery may also have enormous consequences for cancer because cancer doctors can better protect against radiation. The new drugs make it possible to treat cancer with radiation as powerful while combating the disease can greatly improve.
Spectacular study results
The process that led to the medical innovation dates back to 2003, when Professor Gudkov with the idea a certain protein produced in bacteria in the intestinal cells use to protect against radiation. Gudkov put a study with two groups of mice.
"We have two groups of mice exposed to lethal radiation," he said. "All the mice in the control deceased a short time. A few days later when I looked in the cage with the mice that had received the protein, I could see that the dodeljke strlaing survived. It is hard to describe how happy we all of us felt. We realized that finally, after so many years and many trials and frustrations we have achieved a breakthrough that kna save millions of lives. "
Prof. Gudkov published the findings of the protein experiment in Science, the world's leading scientific journal, but the discovery of the medication was temporarily withheld because Gudkov and his fellow researchers are awaiting the results of two series of critical studies of the medication on efficacy and safety of the medication.
The first series of experiments was randomly tested more than 650 monkeys. Both groups of monkeys were exposed to radiation, but only one group received the treatment with the protein. The radiation dose was equal to the highest dose to which humans resulting from the Chernobyl incident was exposed.
The experiment results were very dramatic: 70% of the monkeys were given the medicine are not deceased, while the monkeys who survived suffered from various diseases and disorders related to the deadly nuclear radiation. However, the group who had received the drug, the researchers saw almost all the surviving monkeys. Most of them without any side effects. The tests showed that injecting the drugs in the period between 24 hours before exposure and 72 hours after exposure achieved similar results.
Another test for people who were exposed to the medication without radiation showed that the drugs were safe and showed no side effects were. Prof. Gudkov's Institute is now for further tests on the safety studies done through a short study of criteria that meet the approval requirements for medical experiments under bio-verdedigingsmedicijjnen. A process that is expected to be completed by mid 2010. If resutlaten from these studies confirm the current resutlaten an approval for mass production of these drugs by the FDA is expected within a year or two
"Stable, safe and easy to inject
The subcontractor in Europe is already being prepared to switch to mass production. Meanwhile, the Israeli government in Israel in the short terkijn already going to purchase the drugs, even though they are still in the process of approval. In particular, the medication used in treatment of cancer is not a vaccine but a preventive drug is administered via one or moreinjections.
The drugs work by suppressing, switching off the "suicide mechanism of the cells affected by radiation, while the drug correctly requires the cells to recover from the radiation-induced damage.
Prof. Gudkov who heads a group of Jewish-American scientists have collaborated with Israeli scientists and Israeli investors. Much of the development of these drugs was funded by the U.S. military and Health departments, which until now went out to $ 40 million for the project. Two weeks ago, the U.S. Defense Department announced that in light of the successful tests, the project will continue to fund
Medication That can-protect humans against nuclear radiation Has Been developed by Jewish-American scientists in Cooperation with a researcher and investors from Israel. The full story behind the dramatic discovery published in Yedioth Ahronoth Will Be's weekend edition.
Here's the original article to read
The Process That led up to the medical innovation dates back to 2003, When Professor Gudkov Came up with the idea or Produced Using a bacterial protein found in the inte tine to protect cells from radiation.
Prof. Gudkov published The Findings of the protein experiment in Science, the world's leading scientific journal, however, the discovery of the medication was Kept Secret Until now, while Gudkov and his associated waited for the results of two series of critical tests Examining the medication's effectiveness and safety.
The first series of tests included experiments on More Than 650 monkeys. Each test featured two groups of monkeys Exposed to radiation, but only one group was Given the medication. The radiation dosage was equal to the Highest dosage sustained by humans as result of the Chernobyl mishap.
Were the experiment results are dramatic: 70% of the monkeys That did not receive the cure died, while the Ones That survived suffered from the maladies associated with Various Artists lethal nuclear radiation. However, the group did receive That shot saw the anti-radiation "almost all monkeys survive, must or themself without Any side-effects. The tests showed That inject the medication Between 24 hours before exposure to the 72 hours following the exposure achieves similar results.
Another test on humans, who Were Given the drug without being Exposed to radiation, showed thats the medication does not have side-effects and is safe. Prof. Gudkov's company now needs to expand the safety tests, a process expected to be completed by mid-2010 through a Shortened test track approved drugs for bio-defense. Should experiments ongoing at the current rate, the medication is estimated time to be approved by the FDA for use within-a year or two.
The medication works by suppressing the "suicide mechanism" or cells hit by radiation, while enabling themself to recover from the radiation-induced damages themself That Prompted to activate the suicide mechanism in the first place.
Prof. Gudkov heads a group of Jewish-American scientists and rated HAS microscope with an Israeli researcher and Israeli investors. A large part of the revolutionary medication's development process was funded by the U.S. Defense and Health departments, Which Galanthus far earmarked collateral $ 40 million to the project. About two weeks ago, the U.S. Defense Department Announced That in light of the successful tests, it continued willing to fund the project.
Researchers in England have discovered why the bacterium Deinococcus radiodurans bljikt insensitive to large dose of radiation and even 2000 times the radiation dose for a man who survives could prove fatal. The researchers found that a large quantity of manganese in the cells protects the bacteria with a low level of iron at that time and even the damage of free radicals seems to recover. The bacterium seems to be a sort of shield to protect its cells around the building so that no radiation damage can be directed to the healthy cells. Although still seems premature for this finding is important because cancer patients suggest that it is possible to artificially increase the levels of manganese in healthy cells during radiation efffect of radiation than would be much higher and the side effects could be much lower than it is today , the researchers said. Interestingly it also vitamin E. known for years and has proven to increase the effect of radiation and reduce the side effects. In this study, the researchers also note that vitamin E shows a great similarity with manganese eg tip from our side but always consult a physician for this: radiation injury to the skin is very easy to prevent and repair liver by ordinary ointment such as Kees has suffered, see his story with cancer . In addition, he used everyday computing an extra vitamin E-400 capsule. Consult your doctor if you want to do something but this seems sensible.
Secret of radiation-proof bugs Proposed
Helen Pearson
May internal antioxidant shield cells from radiation damage.
Deinococcus radiodurans survives extreme blasts or radiation.
© Alexander Vasilenko
U.S. researchers have come up with a novel theory for how a tiny, tough bacterium can-survive radiation doses 2000 times or Those That Would fry a person.
The unassuming red bacterium, called Deinococcus radiodurans, was discovered around 50 years ago in a batch of irradiated meat. Ever since, scientists have wondered how it can-radiation mode with better than Almost Any Other organism in the world. "They're Better Than Cockroaches," says James Imlay micro-biologist at the University of Illinois, Urbana.
Researchers know thats the bug Particularly good at patching up DNA damage wrought by radiation. Now Michael Daly of the uniformed Services University of the Health Sciences in Bethesda, Maryland, and his team have come up with a Possible Explanation why.
Comparing with bacteria by differential sensitivities to radiation, the team found thats the must-resistant bacteria tend to store up high levels of manganese and Relatively low levels of iron. By contrast, the bacteria shrivel That ate up a hint or radiation have little manganese and more iron. Artificially lowering the manganese levels Also made bacteria more susceptible to radiation damage, the team reports in Science1 report. "It was quite stunning to us," Daly says.
The Marvels of manganese
Daly suggests thats the manganese Help to Clear Up Damaging molecules, Such as free radicals, That are released by the bugs' metabolism. This leaves the bacteria in a healing state thier and better-able to patch up DNA Damaged by radiation. To test this theory, the team is now trying to create radiation-resistant strains of Escherichia coli by pumping up Their levels of manganese.
Also if Provesende protective manganese in human cells, Daly foresees numerous therapists. A dose of antioxidant That mimic some of the effects of manganese, Such As Vitamin E Might SafeGuard the cell or Those Who are Exposed to radiation by a nuclear accident, for example.
The discovery Might Also Help Those receiving radiation therapy for cancer, Daly speculates. A Drug That Might Be designed boosts the Amount of manganese in healthy cells, but leaves cancerous ones alone. Would this render the healthy tissue to radiation resistant, and avoid some side-effects of the therapy. "There's some really important stuff here," Daly says.
But Cautions That Imlay Such speculation is premature, Because The radiation-resistant bacteria Might have another reason for high manganese unconnected to Their hardiness. The team needs to show Exactly how bacteria Manganese Helps recover from radiation damage, he says.
Before this, scientists have come up with Other explanations for the robustness of the bacteria. Last year, a team of scientists Proposed That Peculiar circular rings of DNA in the bacteria help themself Patch Up Their Damaged DNA2. But Daly Grew bacteria in thesis rings Which Were That They Were missing and showed just as hardy.
M. Daly, et al Science Xpress, doi: 10.1126/science.1103185 (2004). S. Levin-Zaidman, J. Englander, E. Shimoni, AK Sharma, KW Minton and A. Minsky Science, 299. 254-256 (2003). | Article | PubMed | ISI | chem port |
