Liver cancer.

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RFA: Liver Tumors can also be surgically removed a second time with RFA-Radio Frequency Ablation without consequences for success.

27 June 2002: source: Reuters Health and Ann Surg 2002; 235: 863-871

The message below of a scientific research into the effects ofu000d surgical removal of liver tumors seems very RFA methodalso important for the.u000d It makes no difference whether a liver tumor for the first or second oru000d even third time is removed by surgery. A return ofu000d liver tumors by metastases can thus be under controlu000d brought.

NEW YORK (Reuters Health) Jun 27-Repeat liver resections are as safe and effective as the removal of metastatic colorectal cancer resections first for, according to investigators who evaluated a large patient cohort treated at two surgical oncology centers.
Dr. Yuman Fong, or Memorial Sloan-Kettering Cancer Center in New York, and colleagues prospectively identified 96 patients who were originally treated at their institution between 1986 and 2001, and 30 patients treated at the oncology center at University of Frankfurt in Germany between 1985 and 1999. All 126 patients underwent second resections.
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The 30-day mortality after the second surgery was 1.6% for all 126 patients, and the 30-day complication rate was 28%, which was not significantly higher than mortality after the first hepatic resection, the investigators report in the Annals of Surgery for June.
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During a median follow-up of 58.8 months, the 1-and 5-year survival rates were 86% and 34%. The median overall survival was 37 months.
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Multivariate analysis identified only two independent risk factors: the number of lesions and the size of the largest lesion resection at the second. Multiple lesions increased the relative risk to 2.82 compared with single lesions, while having a tumor > 5 cm increased the risk to 1.89 compared with smaller tumors. Outcome was unrelated to any factors associated with the first resection.
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"In selecting patients for repeat resection," Dr. Fong's team writes, "medical fitness, small solitary tumors, ability to clear all disease, and possibly disease-free interval are the most important criteria for consideration."

Ann Surg 2002; 235: 863-871.