Scientific research on nutrition and natural approaches and resources in cancer. Studieabstracten study and analysis.
Here we list articles and studies or research on cancer in relation to nutrition. With some additional comments other as we found on the Internet. We will complement these articles regularly, but that takes time and we want very carefully. We have tried to research and articles in logical and more or less alphabetical order. Often an article in the name of nutrient - vitamin etc. But sometimes in diets or diet in cancer or cancer type out the first named, including bladder cancer and vitamins in the BA. So take the name of one nutrient or use search to start because of various cancers are also often important studies and articles that are not all in this list.
If there are people who can give us tips like please send us remarkable investigations and we post on the site. (See also reading list ( This list compiled by physician-biologist Erik Valstar has exceeded 1500 and are all randomized trials) and cancer rates ). In addition, a recommendation to information on proven effects of diet and nutritional supplementation in cancer of the book: Nutritional intervention in cancer, a signal to the conventional oncology. Because physician-biologist Dr Engelbert Valstar. The book costs 16.95 and the ISBN number is 90 5860 192 7.
Theophylline, a remedy akin to caffeine significantly reduced side effects of cisplatin-based chemotherapy and protects the kidneys during chemotherapy in patients with various cancers. Article updated July 8, 2011
July 8, 2011: I'm cancer-current to the revised article below is still relevant and informative, so let it stand.
August 9, 2005: Source: J Am Soc Nephrol. February 2005, 16 (2) :452-8. Epub 2004 Dec 8.
Theophylline (a metabolite of caffeine) is randomized study by worsening renal function against chemotherapy with cisplatin significantly. Demonstrated by randomized placebo study with no mention of cancer patients with different cancers. Here is the abstract of this study conducted at the University Hospital Göttingen, Germany and published in 2000, including one study (randomized double-blind) where Thephyline in newborns with perinatal asphyxia in a form (sorry do not dare translate literally) also significantly improved renal function . This natural remedy has so strong therapeutic qualities
Nephroprotection by theophylline in patients with cisplatin chemotherapy: a randomized, single-blinded, placebo-controlled trial.
Benoehr P, Krueth P, Bokemeyer C, Grenz A, Osswald H, Hartmann JT.
Department of Nephrology and Rheumatology, Georg-August-University, Robert-Koch Strasse 40, 37075 Gottingen, Germany. pbenoeh@gwdg.de
The aim of the present study was to Assess the Possible prevention of cisplatin-induced impairment of GFR by theophylline in patients with malignancies Various Artists. The trial design was parallel, randomized, single blinded, and placebo controlled. Patients received cisplatin at a dosage of 50 mg / m (2) Either combined with etoposide, ifosfamide, and epirubicin or with paclitaxel and 5-fluorouracil/folinic acid with the usual Precautions, include a standard hydration scheme before application of cisplatin in Both Arms . In the control arm, placebo was Administered, in the verum arm, patient received theophylline in a loading dose of 4 mg / kg intravenously over 30 minutes before cisplatin, followed by 0.4 mg / kg per min over a minimum of 6 h, and then 350 mg three times daily orally for 4 Consecutive days after completion of chemotherapy. Each patient was reassessed and GFR by renal clearance of inulin within-3 d before and at day 5 after cisplatin chemotherapy. Despite usual Precautions, patients in the placebo group had a 21% Decrease (range, 11 to 31%) or inulin clearance after a single cycle of cisplatin-containing chemotherapy (92.9 + / - 3.4 versus 71.8 + / - 3.5 ml / min; P <0.01). Patients who received theophylline had no deterioration of GFR (91.5 + / - 3.7 versus 90.0 + / - 3.8 ml / min, P> 0.05). No adverse effects have consistently observed bone theophylline application. Conventional Precautions Such As hydration and Osmotic diuresis can not preventDefault a significant or Decrease GFR after a single cycle of cisplatin-containing chemotherapy. The Prophylactic application of theophylline as an intravenous loading dose and oral maintenance regimen May preserve kidney function in terms of GFR.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 15590762 [PubMed - indexed for MEDLINE]
Pediatrics. April 2000, 105 (4): E45.
A randomized, double-blind, placebo-controlled trial of the effects of theophylline on renal function in Prophylactic term neonates with perinatal asphyxia.
Jenike AG, Ceriani Cernadas JM, Gorenstein A, Ramirez JA, Vain N, Armadans M, Ferraris JR.
Department of Pediatrics of the Hospital Italiano, Buenos Aires, Argentina. ajenik@drwebsa.com.ar
BACKGROUND: The kidney is the most damaged organ in asphyxiated full-term infants. Experiments in rabbits and rats have Shown That renal adenosine acts as a vasoconstrictive metabolite in the kidney after hypoxemia and / or ischemia, Contributing to the fall in glomerular filtration rate (GFR) and filtration fraction. Vasoconstriction produced by adenosine can be inhibited by the nonspecific adenosine receptor antagonist, theophylline. Gouyon and Guignard ormed newborn and adult rabbits studies Subjected to normocapnic hypoxemia. Their results showed Clearly thats the hypoxemia-induced drop in GFR Could be avoided by the administration of low doses of theophylline.
OBJECTIVE: This study was designed to determining whether theophylline Could Prevent and / or renal dysfunction Amelio rate in term neonates with perinatal asphyxia.
SETTING: Buenos Aires, Argentina.
STUDY DESIGN: We randomized 51 severe asphyxiated term infants to receive intravenously a single dose or Either theophylline (8 mg / kg study group: n = 24) or placebo (control group: n = 27) during the first 60 minutes of life. The 24-hour fluid intake and the urine volumes were recorded consistently formed the first 5 days of life. Daily volume balances (water output / input ratio and weights) were Determined. Severe renal dysfunction was defined as elevated serum creatinine above 1.50 mg / dL, at least for 2 Consecutive days after a fluid challenge, or rising levels of serum creatinine (.3 mg / dL / day). The estimated GFR was consistently the second to third days of life by endogenouscreatinine clearance (mL/minute/1.73 m2) and Using Schwartz's formula: GFR (mL/minute/1.73 m2) =. 45 x length (cm) / plasma creatinine (mg/100 mL) during the first 5 days of life. Tubular performance was reassessed as the concentration of beta2-microglobulin (beta2M) Determined by enzyme immunoassay, on the first voided urine 12 hours after theophylline administration. The statistical analysis for the evaluation of the differences Between the groups was ormed with Student's t and chi (2) Appropriate testing axis.
RESULTS: During the first day of life, the 24-hour fluid balance was significantly more positive in the placebo infants compared with the infants Receiving Receiving theophylline. Over the next few days, the change in fluid balance Favored the theophylline group. Significantly higher mean plasma values were recorded in the placebo group from the second to the fifth days of life. Severe renal dysfunction was present in 4 of 24 (17%) infants of the theophylline group and in 15 or 27 (55%) infants of the control group (relative risk: .30, 95% confidence interval: .12 -. 78) . Mean endogenous creatinine clearance of the theophylline group was significantly Increased compared with the creatinine clearance in infants Receiving placebo (21.84 + / - 7.96 vs. 6.42 + / - 4.16). The GFR (estimated by Schwartz's formula) was markedly Decreased in the placebo group. Concentrations were significantly reduced urinary beta2M in the theophylline group (5.01 + / - 2.3 mg / L vs. 11.5 + / - 7.1 mg / L). More Over, 9 (33%) patients of the theophylline group versus 20 (63%) infants of the control group had urinary beta2M above the normal limit (<.018). There was no difference in the severity of the asphyxia Between infants belonging to the theophylline and control groups in regards of Portman's score. Except for renal involvement, a similar frequency or multiple organic dysfunction, include neuro logic impairment was observed in Both groups. The theophylline group Achieved an average serum level of 12.7 micrograms / mL (range: 7.5-18.9 microg / mL) at 36 to 48 hours of live versus traces (an average serum level of .87 micrograms / mg) in the placebo group.
CONCLUSIONS: Our data suggest That Prophylactic theophylline, Given early after birth, HAS beneficial effects on renal dysfunction in asphyxiated Reducing the full-term infants. (Abstract Truncated)
Publication Types:
Clinical Trial
Multicenter Study
Randomized Controlled Trial
PMID: 10742366 [PubMed - indexed for MEDLINE]
