Thyroid Cancer: Radiation therapy for other cancers caused more severe form of thyroid cancer. Article posted April 22, 2009.

April 22, 2009: Source: Arch Otolaryngol Head Neck Surg. 2009; 135 (4) :355-359.

Radiation for other cancers caused more severe form of thyroid cancer. A form of cancer that is treatable in principle. The differences between patients with thyroid cancer or not radiotherapy had previously had been remarkable and is undivided in all respects negative for the patient group at least three years before their disease previously been exposed to radiation:

Whenever a study with patients with thyroid cancer (125 participants) who were previously exposed to radiation were compared with patients with schldklierkanker (534) who never were exposed to radiation are the following differences appear:

Although statistical comparisons were not possible given the study design, the researchers note: "The differences between the groups geconstaterde moetne be taken seriously"

Influence of Previous Radiation Exposure on pathology Features and Clinical Outcome in Patients With Thyroid Cancer

Raewyn M. Seaberg, MD, PhD; Spiro Eski, MD, Jeremy L. Freeman, MD, FRCSC

Arch Otolaryngol Head Neck Surg. 2009; 135 (4) :355-359.

Objective To whethere determining previous radiation exposure to the head and neck pathology is related to Less Favorable and clinical outcome in patient management or after Surgical thyroid cancer.
Author Affiliations: Department of otolaryngology-Head and Neck Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada.

Design Retrospective chart review.

Setting Academic teaching hospital (referral center).

Patients diagnosed ALL patients with thyroid cancer who Exposed to radiation was leg before Surgical Treatment Were Identified retrospectively from the thyroid cancer database at our institution (1963-2007). One hundred twenty-five patiënten (95 women and 30 men) Were included. Inclusion criteria included Surgical treatment for thyroid cancer and a history of exposure to radiation at least 3 years before diagnosis of the disease.

Main Outcome Measures pathology features and data related to Disease Recurrence, distant metastasis, and survival.

Results Mean (range) age at first exposure to radiation was 19.4 (1-65) years, and mean lag time to diagnosis of disease was 28.7 (3-60) years. Patients Were Treated surgically with Either total or near-total thyroidectomy (83%) or partial or subtotal thyroidectomy (17%). Pathology diagnoses included 111 papillary carcinomas (89%). Sixty-three percent of Patients had multifocal disease, 12% had lymphovascular tumor invasion, and 26% had extrathyroid direct extension of disease. Twenty-five cent of Patients had metastases to cervical lymph nodes, and 9% had distant metastases. Sixteen percent of Patients Experienced Local Recurrence of disease. At last follow-up, 86% of Patients Were alive and free of disease, 8% Were alive with disease, 4% had died of thyroid cancer, and 2% had died or an Unrelated cause. Compared with Other Patients with thyroid cancer, this Radiation-Exposed cohort was more Likely to undergo total thyroidectomy, multiple operative procedures, and external radiotherapy. A higher proportions had multifocal disease, extrathyroid extension, stage IV disease, and distant metastases. At follow-up, Fewer patiënten Were free of disease, and more had died or patiënten thyroid disease.

Conclusion Patients who Have Been Exposed to radiation have more aggressive disease and worse clinical outcome Than Other Patients with thyroid cancer.