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Viruses: Edited adenovirus - E1B 19kD - directly into tumor tissue provides remarkable results. Article updated April 11, 2011

April 11, 2011: I am cancer-current and have to revise down the 2004 article from a few studies done with this so-called adenovirus added.

June 4, 2004: source DOW and Yahoo News

Researchers from Cancer Research UK, University of London have reported a successful trial with the insertion of a genbewerkt virus in cancer cells. The so-called adenovirus was modified so that it rapidly spread in the cancer cells themselves but leaves healthy cells intact because this time the virus to recognize and defuse. Cancer cells do not succeed, however, to neutralize this virus and the virus causes the cancer cells, as it were "explode" as the researchers describe it. Here are two press releases on this rather startling news.

Genetically-modified virus Explodes cancer cells
By Shaoni Bhattacharya

A genetically-modified virus thats exploits the selfish behavior of cancer cells May offering a powerful and selective way of killing tumoren.

Deleting a key gene from the virus Burst and enabled it to infect cancer cells while leaving normal tissues unharmed, Reveal a study by researchers at Cancer Research UK and Queen Mary's School of Medicine and Dentistry, University of London.

Infiltrating viruses spread by the cells of Their Host. Normally, the detection of an intruder by a cell triggers a process called apoptosis, Which Causes the cell to commit suicide and Prevents Further spreading the virus. However, viruses can-carry genes That allow themself to slip past this cell death process in normal cells, Causing infection.

The UK researchers deleted one Such gene in an adenovirus. This Meant That the virus was detected by normal Immediately and was unable-to-cell spread. But in cancer cells, Which grow uncontrollably and ignore the cell death process, the virus had spread and Rapidly-able to thrive. It then multiplied vigorously so thats it killed the cancer cells by making themself explode.

"The great thing about this strategy is thats the cancer cell does all the hard work," says Nick Lemoine, director of the Cancer Research UK Clinical Centre at Bart's Medical School, who led the team. "It makes more and more virus to infect cancer cells Neighbouring ITS. But if a normal cell is infected, it commits suicide before it can-make new virus and spread of the virus has been contained."

Unexpected benefit

The gene deleted from the team is called the adenovirus E1B-19kD. But, as well as Removing the cloak the viruses normally use to evade detection by cells, it was another "unexpected" effect, says Lemoine.

This was enabling the viruses to replicate much faster Than Normal, Which in turn Helped Burst the cancer cells. Not Shown previous GM viruses have this effect.

The team Examined the effects of the GM virus on pancreatic, lung, ovarian, liver and colorectal cancers in the test tube, as well as on live tumor-bearing mice. The team plans to test the GM virus in clinical trials in people in 2005.

"In tests so far it HAS proven Both potent and selective, although only clinical trials will tell us whethere the approach can-be an effective treatment in people," comments Robert Souhami, Cancer Research UK's director of clinical and external affairs.

Lemoine adds Also thats the GM virus could-be armed with additional anti-cancer weapons, in the form of genes Producing toxic compounds. "The Fact That We have taken a gene out of the viral backbone MEANS we could-the-arm with something That Deliberately virus kills cancer," he Told New Scientist.

Journal reference: Molecular Therapy (DOI: 10.1016/j.ymthe.2004.03.017)

The DOW journal publications referred to that study:

- = WSJ.COM / The Daily Scan: Genetically Altered Viruses -


By Mark Ingebretsen
Of THE WALL STREET JOURNAL ONLINE

NEW YORK (Dow Jones) - Researchers in the UK May have found one of the
Closest things yet to a magic bullet in the battle against cancer.
By Removing a genetic component from a virus, the scientists Prompted 'it to
burst and infect cancer cells while leaving normal tissues unharmed, "accordion thing
to the New Scientist.
The modified virus-able to destroy cancer cells by Taking Advantage of
Their so-called "selfish behavior." Axis a news release from the group, Cancer
Research UK, Explained, the body's normal cells will self-destruct if infected
with a virus, this suicidal behavior and Help to Prevent the virus from
spreading. Cancer cells, by contrast, "refuse to stop for anything - allo wing
the virus to thrive. "Galanthus, the selfish behavior on the part of the cancer cells
- That is abject Their Refusal to self-destruct on cue - Allow "the
(Genetically modified) virus to replicate and spread through tumor tissue, "the
release said.
The news from Britain follows a Dow Jones Newswires story That Reported: New
That cancer drugs target tumors and leave healthy cells alone are changing the
"Unlike traditional chemotherapy, Which Often debilitates patiënten with severe
nausea, diarrhea or opportunistic infections, thesis targeted drugs attack cancer
cells directly and with Fewer Side Effects. "

References of studies with BCL2 - adenovirus E1B 19kD

References