Breast cancer and nutrition impact and nutrients: Vitamin D. has benefit and provides far less risk of getting breast and ovarian cancer, several studies presented at ASCO 2006. High vitamin D. value eg to give blood 50% lower risk of breast cancer. Article updated May 6, 2011
May 31, 2006: Source: ASCO 2006 and Hopkins Breast Center / artemis
Own production of vitamin D. by sunlight, the risk of getting breast and ovarian cancer significantly reduced. Those are the findings of several studies presented at ASCO 2006.
Thanks to Frank for us the whole article translated literally as good as possible. Below is the original English article.
VITAMIN D EXAMINED: effects on breast and ovarian cancer
(Source - Annual Meeting of the American Association for Cancer Research, April 4, 2006, Washington, DC)
While the risk factors for breast and ovarian cancer, menopause, obesity, family history and specific genetic changes involved, researchers also look at the role of diet in the development and the treatment and prevention of these tumors. At the 97th Annual Meeting of the American Association for Cancer Research, reported that two groups of scientists using sophisticated statistical techniques, their findings of possible preventive properties of Vitamin D against breast cancer. Although scientists had expected that Vitamin D helps prevent breast cancer and perhaps even to treat a population-based studies on the possible connection has been limited. Now, suggest new studies by researchers at the Samuel Lunenfeld Research Institute at the Mount Sinai Hospital in Toronto that "sunshine" vitamin may play a significant role in reducing the risk of breast cancer. The results, based on population data, found that the reduction was most apparent among subjects with the highest levels of vitamin D were exposed when they were young.
By about 576 patients interviewed diagnosed with breast cancer and 1,135 people without cancer had, the scientists discovered that significant reductions in breast cancer in them were found or a job in the outdoors had worked, participated in outdoor activities at a younger age, or consumed cod liver oil or milk. Working in the open air between age 10 tot19 resulted in an estimated 40 percent reduced risk of breast cancer, while frequent outdoor activities between ages 10 to 29 reduced breast cancer risk by 35 percent gschat. "These outdoor activities include those activities that entailed no physical activity," said Julie Knight, who led the Mount Sinai research team. "And we believe that this evidence of a reduction in the risk of breast cancer associated with sun exposure at an early age."
For dietary influences on cancer development, taking cod liver oil between ages 10 to 19, reduced the risk of breast cancer by about 25 percent, and consuming at least nine glasses of milk every week between ages 10 to 29 reduced the risk by 35 percent. The dietary and lifestyle reductions were significant even when adjusted for other risk factors for breast cancer such as age, membership of a particular race, close relatives with breast cancer, age at menstruation and age at first birth of a woman. "Where you will be exposed to during breast development may be particularly important in determining the future risk of breast cancer," said Knight. "The current thinking is that exposures during adolescence or before a full-term pregnancy have a greater effect, as that is when breast tissue is the fastest developing over." Knight emphasizes that these findings are preliminary estimates of the risk reduction of breast cancer by vitamin D is achieved. The researchers are now looking to corroborate these findings and determine whether physical exercise in the open air at least is associated with breast cancer.
Another report was presented at the conference found that higher doses of dietary vitamin D may help prevent breast cancer, the optimal level of intake of Vitamin D three times the current average for Americans, according to researchers from the University of California, San Diego . Previous studies suggested a link between vitamin D deficiency and more cases of breast cancer. Cedric Garland, Dr.. PH, and Edward Gorham, Ph.D., of UCSD, and their colleagues examined existing cancer studies to determine whether higher levels of vitamin D in the blood could reduce the risk of cancer. "There is a strong inverse dose-response relationship between serum 25-hydroxyvitamin D and risk of breast cancer," said Garland."It is almost a linear model," signifying that higher amounts of 25-hydroxyvitamin D in serum resulted in reduced risk of breast cancer. The evidence pointed to a further level of Vitamin D measured in blood that correlated with a 50 percent reduction in breast cancer cases.
Garland, Gorham and their colleagues studied a serum Vitamin D metabolite known as 25-hydroxyvitamin D and its association with breast cancer in a pooled study that included 1,760 women. The studies, the data provided for the pooled analysis, were conducted by Elizabeth R. Bertone-Johnson and colleagues at Harvard, and LC Lowe and associates at Saint George Hospital Medical School in London. According to the pooled analysis, Vitamin D in blood serum equal to 52 nanograms per milliliter was associated with a 50 percent reduced risk of breast cancer. To be closer to a serum concentration of 52 nanograms / milliliter to come, a typical person would not be less than 1,000 International Units (IU) of vitamin D should consume vitamin D through supplements or fortified food to consume. Currently, a typical American consumes only 320 IU of vitamin D per day. The upper limit of vitamin D intake by the National Academy of Sciences has determined is 2400 IU / day, but no toxic effects of intake of vitamin D have been reported for recordings in 3800 IU per day.
"There is no real downside to a serum level of 52 nanograms per milliliter of Vitamin D," said Gorham. "Such levels are common in sunny climates. There is no known adverse effect of serum levels below 160 nanograms per milliliter." However, since many people use sun protection and work in occupations in or changing services, dietary supplements and vitamin D fortified food necessary for optimal levels of vitamin D to maintain, the scientists noted.
High intakes of calcium, which can occur when taking Vitamin D supplements containing calcium may increase the risk of kidney stones, they warn. However, the dosage level of vitamin D associated with kidney stones in patients far exceeded 3,800 IU / day until more studies are completed, the scientists advised that everyone at least 1,000 IU / day of vitamin D3 consume.
Vitamin D Examined for Impact on Breast and Ovarian Cancers
While risk factors for breast and ovarian cancers include menopause, obesity, family history and specific genetic Mutations, researchers are Also looking at the role of diet in the development, as well as the prevention and treatment of tumors thesis. At the 97th Annual Meeting of the American Association for Cancer Research, two groups of scientists Using sophisticated statistical techniques report Findings and Their Possible preventive properties of Vitamin D against breast cancer.
Though scientists have Suspected That Help to Prevent Vitamin D and may possibly even treat breast cancer, population-based studies on the Possible link and few have bone or limited scope. Now, new studies by researchers at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital in Toronto suggest the "sunshine" vitamin May play a significant role in Reducing breast cancer risk. The results, based on population data, found the reduction was apparent among subjects must Exposed to the Highest Level of vitamin D When They Were Young. By interviewing about 576 patients who had bone diagnosed with breast cancer and 1,135 people who had no cancer, the scientists discovered That significantly Reduction in breast cancer Were found in Those Who had Either Worked in an outdoor job, had taken part in outdoor activities When young , or Consumed cod liver oil or milk.
Working an outdoor job Between ages 10 to19 resulted in an Estimated 40 percent of Reduced risk of breast cancer, while frequent outdoor activities Between ages 10 to 29 lowered breast cancer risk by an Estimated 35 percent. "These outdoor activities included involvement Those That Did not physical activity," said Julie Knight, who headed the Mount Sinai research team. "And so we believe That this is evidence of a reduction or breast cancer risk, associated with EARLIER exposure to the sun."
For Dietary Influences on cancer development, Taking cod liver oil Between ages 10 to 19 Reduced breast cancer risk by about 25 percent, and consuming at least nine glasses of milk everytime week Between the ages of 10 to 29 Reduced the risk by 35 percent. The dietary and lifestyle réductions Were significantly, even When adjusted for Other risk factors for breast cancer Such As Age, ethnicity, close relatives with breast cancer, age at menarche and age at a woman's first birth."What You Are Exposed to consistently breast development May Be Particularly important in Determining future breast cancer risk," Knight said. "Current thinking is constantly exposures That adolescence or before a full-term pregnancy May Have A Greater Impact, ash That is when breast tissue is going through the rapid development musts."
Knight emphasizes That thesis Findings are preliminary estimates of the risk reduction of breast cancer Brought about by Vitamin D. The researchers are now looking to solidify thesis Findings, and determining whethere physical exercise while outdoors in any way associated with breast cancer. Another report presented at the conference found That Increasing doses of dietary Vitamin D May Help Prevent Breast Cancer, with the optimal level of intake of Vitamin D more That three times the current average for Americans, According To researchers from the University of California, San Diego . Previous studies have a Suggested Link Between Vitamin D deficiency and higher incidence of breast cancer. Cedric Garland, Dr.. PH, and Edward Gorham, Ph.D., of UCSD, and Their Colleagues Examined Existing cancer studies to determining if higher Vitamin D levels in the blood could-reducing the risk of cancer.
"There is a strong inverse dose-response relationship Between the concentration of serum 25-hydroxyvitamin D and the risk of breast cancer," Garland said. "It's a close fit to a linear model," Meaning That higher Amount of 25-hydroxyvitamin D in the serum resulted in Decreased risk of breast cancer. Further the evidence pointed to a level of Vitamin D That Measured in blood correlated with a 50 percent reduction in the incidence of breast cancer.
Garland, Gorham and Their Colleagues studied a serum Vitamin D metabolite Known As 25 hydroxyvitamin D and Its Association with breast cancer occurrence in a pooled That study included 1760 women. The Studies That Provided the data for the pooled analysis Were Conducted by Elizabeth R. Bertone-Johnson and colleagues at Harvard, and LC Lowe and associates at Saint George's Hospital Medical School in London. Accor ding to the pooled analysis, Vitamin D in blood serum equal to 52 nanograms per milliliter was associated with a 50 percent Reduced risk of breast cancer. To move closer to a serum concentration of 52 nanograms / milliliter, a typical individual Would have to consume no less Than 1,000 International Units (IU) of Vitamin D Every day, through supplements or vitamin D-fortified foods. Currently, a typical American consumes only 320 International Units of Vitamin D a day. The upper limit for vitamin D intake Established by the National Academy of Sciences is 2,400 IU / day, but no toxic effects of vitamin D intake Have Been Reported for intakes below 3,800 IU per day.
"There is no Substantial downside to a serum level of 52 nanograms per milliliter or Vitamin D," said Gorham. "Such levels are common in sunny Climates. There is No known adverse effects or serum levels below 160 nanograms per milliliter." However, since many people use sunscreens and are Involved in indoor Occupations or shift work, dietary supplements and vitamin D fortified foods are Necessary to Maintain optimal levels of Vitamin D, the scientists noted. High intakes of calcium, Which Could occure with intake of Vitamin D supplements containing calcium, Could Increase the Risk of kidney stones, They warn. However, the dosage level of vitamin D associated with kidney stones in Far Exceeded patiënten 3800 IU / day. Until more studies are completed, the scientists recommended That everyone consume at least 1000 IU / day of vitamin D3.
SOURCE: Annual Meeting of the American Association for Cancer Research, April 4, 2006, Washington, DC
