3 maart 2021: Bron: Journal of the anus, rectum and colon.

Constipatie komt veel voor bij patiënten met de ziekte van Parkinson en die constipatie kan ernstige problemen veroorzaken. Tot aan overlijden aan toe. Uit een dubbelblinde en gerandomiseerde placebo gecontroleerde studie blijkt dat probiotica - melkzuurbacteriën de problemen met constipatie kunnen verlichten en verbeteren.

Het gemiddelde aantal wekelijkse spontane stoelgangen nam toe in de behandelingsgroep met 1,0 - 1,2 keer vanaf de 2 weken dat met de probiotica werd begonnen tot de laatste 2 weken van de studie (baseline, 2,6), en nam af met 0,3 in de placebogroep (baseline, 2.8). Secundaire uitkomsten, waaronder kwaliteit van leven gerelateerd aan constipatie, waren ook gunstig voor de actieve behandeling. Er werden geen ernstige bijwerkingen gezien.

Op de website waar deze studie is gepubliceerd kunt u een PDF downloaden van de studie:

Lewy body constipation

  1. Sakakibara R, Doi H, Fukudo S. Lewy body constipation. J Anus Rectum Colon. 2019;3(1):10-17. 
Ryuji SakakibaraHirokazu DoiShin Fukudo
Author information

Abstract

We systematically reviewed literature regarding "Lewy body constipation", i.e., constipation due to Lewy body diseases (LBD), with minimal neurologic symptoms. Epidemiology and pathology studies showed that LBD can start with constipation alone, mostly due to neuronal loss and appearance of Lewy bodies in the myenteric plexus. Because LBD significantly increases with age, "Lewy body constipation" may also increase with age. Neuroimaging methods such as metaiodobenzylguanidine (MIBG) scintigraphy and dopamine transporter (DAT) scan provide a way to detect "Lewy body constipation." Key for "Lewy body constipation" includes minimal non-motor features such as REM sleep behavior disorder (night talking). Add-on therapy may be required to ameliorate constipation in patients. Diagnosis is not always easy; therefore, collaboration of gastroenterologists and neurologists is highly recommended to maximize patients' quality of life. In conclusion, "Lewy body constipation" might become a distinct category among geriatric constipation, regarding patients' follow-up and their management.

Fullsize Image

References (46)

    • 2. Ghoshal UC. Chronic constipation in Rome IV era: The Indian perspective. Indian J Gastroenterol. 2017; 36: 163-73.

    • 3. Drossman DA, Chang L, Chey WC, Kellow J, Tack J, Whitehead WE, etd. Rome IV Functional Gastrointestinal Disorders: Disorders of Gut-Brain Interaction, Volume 1 and 2, Rome Foundation, Inc., New York, 2017.


    • 5. Tateno F, Sakakibara R, Kishi M, Ogawa E, Takada N, Hosoe N, et al. Constipation and metaiodobenzylguanidine myocardial scintigraphy abnormality. J Am Geriatr Soc. 2012; 60: 185-7.

    • 6. Sakakibara R, Tateno F, Kishi M, Tsuyusaki Y, Terada H, Inaoka T. MIBG myocardial scintigraphy in pre-motor Parkinson's disease: a review. Parkinsonism Relat Disord. 2014; 20: 267-73.

    • 7. Tateno H, Sakakibara R, Tateno F, Tuyusaki Y, Aiba Y, Kishi M, Tateno A, Ogata T, Doi H, Inaoka T, Terada H, Suzuki Y. Metaiodobenzylguanidine myocardial scintigraphy identifies premotor parkinson's disease during a negative dopamine transporter scan. J Am Geriatr Soc. 2015; 63: 2428-30.



    • 10. Nuvoli S, Palumbo B, Malaspina S, Madeddu G, Spanu A. 123I-ioflupane SPET and 123I-MIBG in the diagnosis of Parkinson's disease and parkinsonian disorders and in the differential diagnosis between Alzheimer's and Lewy's bodies dementias. Hell J Nucl Med. 2018; 21: 60-68.



    • 13. Brandl SJ, Braune S. Sensitivity and specificity of cardiac metaiodobenzylguanidine scintigraphy in the early diagnosis of Parkinson's disease. Clin Auton Res. 2018 Jun 5. doi: 10.1007/s10286-018-0534-y. [Epub ahead of print]


    • 15. Iranzo A, Valldeoriola F, Lomeña F, Molinuevo JL, Serradell M, Salamero M, Cot A, Ros D, Pavía J, Santamaria J, Tolosa E. Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study. Lancet Neurol. 2011; 10: 797-805.



    • 18. Gelpi E, Navarro-Otano J, Tolosa E, Gaig C, Compta Y, Rey MJ, Martí MJ, Hernández I, Valldeoriola F, Reñé R, Ribalta T. Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders. Mov Disord. 2014; 29: 1010-8.


    • 20. McCann H, Cartwright H, Halliday GM. Neuropathology of α-synuclein propagation and braak hypothesis. Mov Disord. 2016; 31: 152-60.



    • 23. Svensson E, Horváth-Puhó E, Thomsen RW, Djurhuus JC, Pedersen L, Borghammer P, Sørensen HT. Vagotomy and subsequent risk of Parkinson's disease. Ann Neurol. 2015; 78: 522-9.



    • 26. Weng Y, Qi R, Liu C, Ke J, Xu Q, Wang F, Zhang LJ, Lu GM. Disrupted functional connectivity density in irritable bowel syndrome patients. Brain Imaging Behav. 2017; 11: 1812-22.

    • 27. Schaller BJ, Graf R, Jacobs AH. Pathophysiological changes of the gastrointestinal tract in ischemic stroke. Am J Gastroenterol. 2006; 101: 1655-65.

    • 28. Sakakibara R. Cyclic vomiting syndrome: the nervous system has the guts. Clin Auton Res. 2018; 28: 167-9.

    • 29. Mukherjee A, Biswas A, Das SK. Gut dysfunction in Parkinson's disease. World J Gastroenterol. 2016; 22: 5742-52.

    • 30. Bestetti A, Capozza A, Lacerenza M, Manfredi L, Mancini F. Delayed gastric emptying in advanced Parkinson disease: correlation with therapeutic doses. Clin Nucl Med. 2017; 42: 83-7.

    • 31. Tateno F, Sakakibara R, Kishi M, Ogawa E, Yoshimatsu Y, Takada N, Suzuki Y, Mouri T, Uchiyama T, Yamamoto T. Incidence of emergency intestinal pseudo-obstruction in Parkinson's disease. J Am Geriatr Soc. 2011; 59: 2373-5.

    • 32. Ogawa E, Sakakibara R, Kishi M, Tateno F. Constipation triggered the malignant syndrome in Parkinson's disease. Neurol Sci. 2012; 33: 347-50.

    • 33. Tateno F, Sakakibara R, Aiba Y, Tsuyusaki Y, Kishi M, Tateno H, Ogata T. Stercoral ulcer and colonic perforation in an individual with Parkinson's disease with constipation. J Am Geriatr Soc. 2016; 64: e118-20.

    • 34. Tateno F, Sakakibara R, Yokoi Y, Kishi M, Ogawa E, Uchiyama T, Yamamoto T, Yamanishi T, Takahashi O. Levodopa ameliorated anorectal constipation in de novo Parkinson's disease: The QL-GAT study. Parkinsonism Relat Disord. 2011; 17: 662-6.

    • 35. Tateno H, Sakakibara R, Shiina S, Doi H, Tateno F, Sato M, Masaka T, Kishi M, Tsuyusaki Y, Aiba Y, Ogata T, Suzuki Y. Transdermal dopamine agonist ameliorates gastric emptying in Parkinson's disease. J Am Geriatr Soc. 2015; 63: 2416-8.


    • 37. Takano S, Sands DR. Influence of body posture on defecation: a prospective study of "The Thinker" position. Tech Coloproctol. 2016; 20: 117-21.

    • 38. Zangaglia R, Martignoni E, Glorioso M, Ossola M, Riboldazzi G, Calandrella D, Brunetti G, Pacchetti C. Macrogol for the treatment of constipation in Parkinson's disease. A randomized placebo-controlled study. Mov Disord. 2007; 22: 1239-44.

    • 39. Sakakibara R, Yamaguchi T, Uchiyama T, Yamamoto T, Ito T, Liu Z, Odaka T, Yamaguchi C, Hattori T. Calcium polycarbophil improves constipation in primary autonomic failure and multiple system atrophy subjects. Mov Disord. 2007; 22: 1672-3.



    • 42. Sullivan KL, Staffetti JF, Hauser RA, Dunne PB, Zesiewicz TA. Tegaserod (Zelnorm) for the treatment of constipation in Parkinson's disease. Mov. Disord. 2006; 21: 115-6.

    • 43. Sakakibara R, Doi H, Sato M, Hirai S, Masaka T, Kishi M, Tsuyusaki Y, Tateno A, Tateno F, Aiba Y, Ogata T, Suzuki Y. Nizatidine ameliorates slow transit constipation in Parkinson's disease. J Am Geriatr Soc. 2015; 63: 399-401.



  • 46. Cadeddu F, Bentivoglio AR, Brandara F, Marniga G, Brisinda G, Maria G. Outlet type constipation in Parkinson's disease: results of botulinum toxin treatment. Aliment Pharmacol. Ther. 2005; 22: 997-1003.



Plaats een reactie ...

Reageer op "probiotica - melkzuurbacterien verbeteren constipatie bij patiënten met de ziekte van Parkinson."


Gerelateerde artikelen
 

Gerelateerde artikelen

Mediterrane dieet staat op >> Gezondheidsraad adviseert >> Plantaardige voeding en bewegen >> Mediterraan dieet plus olijfolie >> Gepersonaliseerd dieet gesplitst >> Sterk bewerkte voedingsmiddelen >> Vitamine D-suppletie met of >> Mensen die regelmatig fruit >> Dieet met veelal onbewerkt >> Ongezonde leefstijl waaronder >>