Longkanker: informatie over actuele behandelingen en ontwikkelingen bij longkanker. Ook over mesothelioma staat een en ander onder deze artikelenreeks.

Ervaringen van kankerpatienten met complementaire aanpak, waaronder ook psychosociale hulp, zijn te vinden onder ervaringsverhalen en er zijn op onze website ook een aantal video's van kankerpatienten te zien, aan te klikken via videoknop linksbovenaan op deze pagina. Of ga naar de website van het SNFK waar o.a. een video voorlichtingsfilmpje is te zien over psychosociale ondersteuning bij kanker.

Als u ons wilt ondersteunen dan kan dat via een donatie: zie inschrijving OPS

Voor min of meer onafhankelijke informatie over wat longkanker is en hoe dit naar de nieuwste inzichten wordt behandeld kunt u als u hier klikt ook Wikipedia raadplegen.

Scroll in linkerkolom naar de artikelen die wij op min of meer alfabetische volgorde hebben gerubriceerd op naam medicijn of behandeling of bv. patiëntenervaringen, psychosociale hulp, vaccins enz. .

Cryosurgery - bevriezen van tumoren - bij longtumoren ook succesvol en hoopgevend.

d.d. 4 december 2003:
Nieuwe studies met cryosurgery (bevriezen via holle naald door huid heen) bij longtumoren lijken beloftevol en succesvol, aldus nieuwe klinische data gepresenteerd op de RSNA ( the 89th Scientific Assembly and Annual Meeting of the Radiological Society of North America). In verschillende studies zijn 187 patiënten met 234 longtumoren met deze nieuwe techniek behandeld en volgens de onderzoekers verdwenen de tumoren zonder echt zichtbare vervelende bij-effecten bij het overgrote deel van de behandelde patiënten. Voordeel van deze techniek is ook dat er geen narcose meer aan te pas komt en slechts plaatselijk verdoofd wordt. Ook is bij longtumoren bevriezen te prefereren boven RFA - Radio Frequency Ablation - omdat er veel minder vochtontwikkeling bij komt waardoor de benauwdheid voor patiënten veel minder is. We hebben gezocht op internet naar abstracten van deze studies maar nog niet kunnen vinden. Wel veel studies van cryosurgery bij prostaat- en levertumoren en op de website van Endocare staat een uitgebreide beschrijving wat cryosurgery precies is en welke technieken ervoor worden gebruikt.

-- PRESS RELEASE: New Study on Percutaneous Thoracic Cryotherapy Promises Breakthrough --

IRVINE, Calif., Dec. 2 /PRNewswire-FirstCall/ -- Endocare Inc. (OTC: ENDO), an innovative medical device company focused on the development of minimally invasive technologies for tissue and tumor ablation, today announced that new clinical data presented at the 89th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA) in Chicago shows that CT-guided, percutaneous lung cryotherapy (PLC) can be very effective in treating lung cancer tumors and results in minimal patient discomfort and minimal damage to adjacent tissues.

The study, presented today by Dr. Peter Littrup, Professor of Radiology at Wayne State School of Medicine, is a summary of the results of PLC performed on 187 patients with 234 total lesions. 217 PLC sessions were administered over a 13-month period. Treatment efficacy among patients in the study was high and at six months follow-up, the vast majority of treated areas were stable, smaller than the original tumor site or were destroyed completely. PLC involves the use of a slender cryoprobes inserted through the skin directly into the tumor. Extreme cold is then directed to the tumor, freezing the cancer cells. Most PLC patients receive only local anesthesia with minimal or no sedation, as compared to open surgery, which involves general anesthesia and a longer hospital stay. "This study is valuable in demonstrating the ability to treat lung tumors of various sizes and locations with cryotherapy," said Dr. Littrup. "An advantage of cryotherapy over radio frequency was noted in the relatively low rate of pneumothoraces [air pockets] that developed as a result of cryo, and the relative ease of managing them." Dr. Littrup continued, "In addition, patients with advanced disease felt significantly better within one week of cryotherapy." Endocare estimates that the total market opportunity to treat unresectable lung lesions exceeds $400 million annually.

About Endocare
Endocare Inc. -- www.endocare.com -- is an innovative medical device company focused on the development of minimally invasive technologies for tissue and tumor ablation. Endocare has initially concentrated on developing devices for the treatment of prostate cancer and believes that its proprietary technologies have broad applications across a number of markets, including the ablation of tumors in the kidney, lung, liver and bone. Referenties van cryosurgery bij vooral prostaatkanker en levertumoren zoals Endocare die opgeeft

1. Parker SL, Tong T. Bolden S, et al. Cancer statistics 1997. CA Cancer J Clin 1997;47:5-27.
2. Zhou XD, Tang ZY, Yu YQ. Ablative approach for primary liver cancer: Shanghai experience. Surg Oncol Clin N America 1996;5:379-390.
3. Mc Masters KM, Edwards MJ. Liver cryosurgery: a potentially curative treatment option for patients with unresectable disease. KMA Journal 1996;94:222-229.
4. Ravikumar TS, Kane R. Cady B, et al. A 5-year study of cryosurgery in the treatment of liver tumors. Arch Surg 1991;126:1520-24.
5. Resection of the liver for colorectal carcinoma metastases; a multi-institutional study of indications for resection - Registry of hepatic metastases. Surgery 1988;103:278-288.
6. Cooper IS. Cryogenic surgery: a new method of destruction or extirpation of benign or malignant tissues. New Engl J Med 1963;268:743-749.
7. Onik GM, Cooper C, Goldberg HI, et al. Ultrasonic characteristics of frozen liver. Cyrobiology 1984;21:321-328.
8. Onik GM, Gilbert J, Hoddick W, et al. Sonographic monitoring of hepatic cryosurgery in an experimental animal model. AJR 1985;144:1043-47.
9. Onik GM, Atkinson D, Zemel R, et al. Cryosurgery of liver cancer. Semin Surg Oncol 1993;9:309-317
. 10. Weaver ML, Atkinson D, Zemel R. Hepatic cryosurgery in treating colorectal metastases. Cancer1995;76:210-214.
11. Lee FT Jr., Mahvi DM, Chosy SG, et al. Hepatic cryosurgery with intraoperative ultrasound guidance. Radiology 1997;202:624-632. 12. Ravikumar TS. Interstitial therapies for liver tumors. Surgical Oncology Clinics of North America 1996;5:365-377.
13. Kruskal JB, Kane RA. Intraoperaitve ultrasonography of the liver. Crit Rev Diagn Imaging 1995;36:175-226.
14. Ravikumar TS, Steele GD Jr. Hepatic cryosurgery. Surg Clin North Am 1989;69:433-440.
15. Weaver ML, Atkinson D, Zemel R. Hepatic cryosurgery in the treatment of unresectable metastases. Surg Oncol 1995;4:231-236.
16. Soyer P, Elias D, Zeitoun G, et al. Surgical treatment of hepatic metastases: impact of intraoperative ultrasound. AJR 1993;160:511-514.
17. Haider MA, Leonhardt C, Hanna SS, et al. The role of intraoperative ultrasonography in planning the resection of hepatic neoplasms. Can Assoc Radiol J 1995;46:98-104.
18. Ravikumar TS, Buenaventura S, Salem RR, et al. Intraoperative ultrasonography of the liver: detection of occult liver tumors and treatment by cryosurgery. Cancer Detect Prev 1994;18:131-138.
19. Gage AA. Current progress in cryosurgery. Cryobiology 1988;25:483-486.
20. Makuuchi M, Takayama T, Kosuge T, et al. The value of ultrasonography for hepatic surgery. Hepatogastroenterology 1991;38:64-70.
21. Rvikumar TS, Steel GD Jr., Kane R, et al. Experimental and clinical observations on hepatic cryosurgery for colorectal metastases. Cancer Res 1991;51:6323-27.
22. Weber SM, Lee FT Jr., Chinn DO, et al. Perivascular and intralesional tissue necrosis after hepatic cryoablation: results in a porcine model. Surgery (in press).
23. Lee FT Jr., Weber SM, Chosy SG, et al. Hepatic cryoablation: ultrasound monitoring accurately predicts the extent of necrosis in normal pig liver. Submitted to Radiology.
24. Tatsuni K, Rubinsky B, Onik G, et al. Effect of thermal variables on frozen human primary prostatic adenocarcinoma cells. Urology 1996;48:441-447.
25. Liu JB, Feld RI, Goldberg BB et al. Laparoscopic gray-scale and color doppler US: preliminary animal and clinical studies. Radiology 1995;194:851-857.
26. Cozzi, PJ, McCall JL, Jorgenson JO, et al. Laparoscopic vs. open ultrasound of the liver; an in vitro study. HPB Surgery 1996;10:87-89.
27. Ravikumar TS. The role of cryotherapy in the management of patients with liver tumors. Advances in Surgery 1996;30:281-291.
28. Lee FT Jr., Chost SG, Weber SM, et al. Hepatic cryosurgery via minilaparotomy in a pig model. Submitted to Journal of Laparoendoscopic Surgery.
29. Livraghi T, Vetorri C. Lazzaroni S. Liver metastases: results of percutaneous ethanol injection in 14 patients. Radiology 1991;179:709-712.
30. Livraghi T, Giorgio A, Marin G, et al. Hepatocellular carcinoma and cirrhosis in 746 patients: long term results of percutaneous ethanol injection. Radiology 1995;197:101-108.
31. Hill CR, ter Haar GR. High intensity focused ultrasound - potential for cancer treatment. Br J Radiology 1995;68:1296-1303.
32. Amin Z, Donald JJ, Masters A. Hepatic metastases: interstitial laser photocoagulation with real-time US monitoring and dynamic CT evaluation of treatment. Radiology 1993;187:339-347.
33. Solbiati L, Lerace T, Goldberg SN, et al. Percutaneous US guided radio-frequency tissue ablation of liver metastases: treatment and follow-up in 16 patients. Radiology 1997;202:195-203.
34. Hahn PF, Gazelle GS, Jian DY, et al. Liver tumor ablation: real-time monitoring with dynamic CT. Acad Radiol 1997;4:634-638.
35. Vallencien G, Harouni M, Veillon B, et al. Focused extra-corporeal pyrotherapy: feasability study in man. J Endoural 1992;6:173-181.
36. Rossi S, DiStasi M, Buscarini E. Percutaneous RF interstitial thermal ablation in the treatment of hepatic cancer. AJR 1996;167:759-768.
37. Goldberg SN, Gazelle GS, Dawson SL, et al. Tissue ablation with radiofrequency using multiprobe arrays. Acad Radiol 1995;2:670-674.
38. Goldberg SN, Gazelle GS, Solbiati L. Radiofrequency tissue ablation: increased lesion diameter with a perfusion electrode. Academic Radiology 1996;3:636-44.
39. Livraghi T, Goldberg SN, Monti F, et al. Saline-enhanced radio-frequency tissue ablation in the treatment of liver metastases. Radiology 1997;202:205-210.
40. Steele G Jr., Bleday R, Mayer RJ, et al. A prospective evaluation of hepatic resection for colorectal metastases to the liver: Gastrointestinal Tumor Study Group Protocol 6584, J Clin Oncol 1991;9:1105-12.
41. Saliken JC, McKinnon JG, Gray R. CT for monitoring cryotherapy. AJR 1996;166:853-855.
42. Matsumoto R, Selig AM, Colucci VM, et al. MR monitoring during cryotherapy in the liver; predictability of histologic outcome. JMRI 1993;3:770-776.
43. Pease GR, Wong ST, Roos MJ, et al. MR image-guided control of cryosurgery. JMRI 1995;5:753-60.
44. Hong JS, Wong S, Pease G, et al. MR imaging assisted temperature calculations during cryosurgery. MRI 1994;12:1021-31.
45. Onik GM. Personal communication. 1997.